En-bloc Resection of Bladder Tumor Versus Conventional Transurethral Resection of Bladder Tumor: Long-term…

Randomized trialEuropean urology focus· Aug 2026

En-bloc Resection of Bladder Tumor Versus Conventional Transurethral Resection of Bladder Tumor: Long-term Oncological Outcomes from a Single-center Prospective Trial.

Francesco Di Bello, Pietro Diana, Andrea Gallioli … Alberto Breda

OncologyRandomized trialTreatmentQ1IF 4.2

En-bloc and conventional bladder tumor resection show similar 5-year recurrence rates

En-bloc Resection of Bladder Tumor Versus Conventional Transurethral Resection of Bladder Tumor: Long-term Oncological Outcomes from a Single-center Prospective Trial.

Francesco Di Bello … Alberto Breda

European urology focus · Aug 2026

Methods

To address gaps in long-term oncologic outcomes, we conducted a post hoc analysis of a single-center randomized trial including 219 of the 248 patients treated between 2018 and 2021, evaluating overall survival (OS), cancer-specific survival (cancer-specific survival), and cumulative incidence of urothelial recurrence with a median follow-up of 60 mo (interquartile range = 53-79).

n = 248 patients

Results

similar recurrence with either technique, en bloc offers no added benefit

cTURBT recurrence

8%

ERBT recurrence

10%

More results

Overall, 77 patients experienced recurrence.

Even after competing-risk multivariable adjustment for overall mortality, as well as age, sex, tumor stage and grade, comorbidities (hypertension and diabetes mellitus), prior bladder tumor, and adjuvant therapy, recurrence rates did not differ between ERBT and cTURBT.

More results

Rates of upgrading (low grade to high grade) and upstaging (Tx/Ta/T1-T2) were also similar between groups.

“

Conclusion

During follow-up, 41 patients died, including 5 bladder cancer-related deaths; 60-month OS was 76% (95% CI = 68-86) for cTURBT and 83% (95% CI = 76-90) for ERBT, with no difference in 60-mo cancer-specific survival (97% vs 97%).

En-bloc Resection of Bladder Tumor Versus Conventional Transurethral Resection of Bladder Tumor: Long-term Oncological Outcomes from a Single-center Prospective Trial.

En-bloc Resection of Bladder Tumor Versus Conventional Transurethral Resection of Bladder Tumor: Long-term Oncological Outcomes from a Single-center Prospective Trial.

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