Antimicrobial Stewardship in Vancomycin-Resistant Enterococcus faecalis : Clinical Study Evaluating…

Cohort studyAntibiotics (Basel, Switzerland)· Jul 2026

Antimicrobial Stewardship in Vancomycin-Resistant Enterococcus faecalis : Clinical Study Evaluating Antimicrobial Susceptibility Patterns and Antibacterial Regimens.

Samantha A Tolbert, Mollie V Day, Aline Arif … Alexandre E Malek

Infectious DiseaseCohort studyClinical practiceQ1IF 5.8

Vancomycin-resistant Enterococcus faecalis was mostly ampicillin-susceptible, yet daptomycin was used most.

Antimicrobial Stewardship in Vancomycin-Resistant Enterococcus faecalis : Clinical Study Evaluating Antimicrobial Susceptibility Patterns and Antibacterial Regimens.

Samantha A Tolbert … Alexandre E Malek

Antibiotics (Basel, Switzerland) · Jul 2026

Background

Vancomycin-resistant enterococci (vancomycin-resistant enterococci) Enterococcus faecalis ( E. faecalis) remains largely ampicillin-susceptible, yet broad-spectrum agents are frequently used empirically (i.e., daptomycin and linezolid).

Purpose

This study aims to describe the antibacterial susceptibility results of Enterococcus faecalis vancomycin-resistant enterococci and assess antibiotics use in clinical settings in a tertiary medical center.

Methods

This was a single-center, retrospective, descriptive study of hospitalized and outpatient adults with Enterococcus faecalis vancomycin-resistant enterococci isolates identified between 1 June 2018 and 15 March 2025.

n = 337 patients

Results

82% of resistant isolates stayed susceptible to ampicillin, a narrower-spectrum option than daptomycin.

29%

Aminopenicillin group

7%

Non-aminopenicillin gr

More results

The most common source of infection was urinary (67%), followed by skin and soft tissue infections and bone/joint infections (11% each).

Antimicrobial regimens varied, with daptomycin being the most used agent (19%).

More results

No patients in the aminopenicillin group experienced 30-day mortality, whereas two patients (3%) in the non-aminopenicillin group died within 30 days.

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Conclusion · 1 of 2

Despite higher susceptibility to ampicillin and nitrofurantoin, daptomycin was the most used agent for vancomycin-resistant enterococci E. faecalis infections.

Conclusion · 2 of 2

These findings highlight a need for improved antimicrobial stewardship and further clinical studies to guide optimal therapy.

Antimicrobial Stewardship in Vancomycin-Resistant Enterococcus faecalis : Clinical Study Evaluating Antimicrobial Susceptibility Patterns and Antibacterial Regimens.

Antimicrobial Stewardship in Vancomycin-Resistant Enterococcus faecalis : Clinical Study Evaluating Antimicrobial Susceptibility Patterns and Antibacterial Regimens.

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