Exploration of SOCS3 and HSPA1A in PANoptosis during acute myocardial infarction and chronic kidney disease.

Mendelian randomization confirmed that chronic kidney disease is a significant risk factor for coronary artery disease.

We identified 12 genes shared by acute myocardial infarction, chronic kidney disease, and PANoptosis, and determined SOCS3 and HSPA1A as key diagnostic genes.

Functional analysis showed enrichment in pathways including JAK STAT signaling and apoptosis.

Animal experiments demonstrated that knockdown of SOCS3 significantly inhibited expression of key PANoptosis molecules such as CASP1, CXCL10, and ZBP1 after MI, reduced inflammation, and improved cardiac function.