Family History and Adherence to Ideal Cardiovascular Health: Counteracting Impacts on the Onset Age of Type 2 Diabetes and Subsequent Cardiovascular Disease Risk.

Compared with individuals without family history, those with family history had HRs (95% CIs) of 3.911 (3.041, 5.032), 3.785 (3.385, 4.233), 3.627 (3.340, 3.938), 3.465 (3.189, 3.764), and 3.169 (2.787, 3.603) for T2D onset at < 40, 40-50, 50-60, 60-70, and ≥ 70 years old, respectively (P interaction = 0.007).

Among individuals with family history, HR (95% CI) for incident cardiovascular disease was 3.598 (1.372, 9.433) for those diagnosed T2D < 50 years compared with those without T2D, while the HR (95% CI) was 2.336 (1.232, 4.428) among those without family history.