Vitrectomy for Proliferative Diabetic Retinopathy with Asteroid Hyalosis: Contemporary Outcomes and…

Cohort studyRetina (Philadelphia, Pa.)· Aug 2026

Vitrectomy for Proliferative Diabetic Retinopathy with Asteroid Hyalosis: Contemporary Outcomes and Challenges.

Justin S Yun, Erin NaPier, Hamid Hosseini, Adrian C Au

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EndocrinologyCohort studyTreatmentQ1IF 2.0

Retinal reattachment succeeded in most eyes despite asteroid hyalosis complicating vitrectomy.

Vitrectomy for Proliferative Diabetic Retinopathy with Asteroid Hyalosis: Contemporary Outcomes and Challenges.

Justin S Yun … Adrian C Au

Retina (Philadelphia, Pa.) · Aug 2026 · Q1 in General Medicine

Purpose

To evaluate the diagnostic and therapeutic outcomes of pars plana vitrectomy (pars plana vitrectomy) in eyes with proliferative diabetic retinopathy (proliferative diabetic retinopathy) complicated by asteroid hyalosis (asteroid hyalosis) in the modern small-gauge era.

Methods

This retrospective series included 12 eyes of 12 patients with asteroid hyalosis who underwent pars plana vitrectomy for proliferative diabetic retinopathy-related complications between July 2023 and August 2025 at a county-based tertiary center.

n = 12 eyes

Results

91.7%

most eyes stayed reattached despite asteroid hyalosis complicating surgery

n = 12 eyes

More results

Mean age was 60.1 years (median 58.5; interquartile range [IQR] 51.3-66.5).

Surgical indications included vitreous hemorrhage in 9 eyes (75.0%) and tractional retinal detachment in 8 (66.7%).

A spontaneous posterior vitreous detachment was absent in 4 eyes (33.3%), and retinal breaks occurred in 6 (50.0%).

More results

Final BCVA was 20/200 or better in 7 eyes (58.3%).

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Conclusion · 1 of 2

Asteroid hyalosis increases vitreoretinal adhesion and intraoperative risk during pars plana vitrectomy for proliferative diabetic retinopathy but does not preclude favorable anatomic outcomes with modern techniques.

Conclusion · 2 of 2

Fluorescein angiography is a valuable adjunct for detecting occult neovascularization and guiding timely surgical intervention when visualization is limited.

Vitrectomy for Proliferative Diabetic Retinopathy with Asteroid Hyalosis: Contemporary Outcomes and Challenges.

Vitrectomy for Proliferative Diabetic Retinopathy with Asteroid Hyalosis: Contemporary Outcomes and Challenges.

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