Successful staged endoscopic treatment of multiple gastrointestinal varices caused by oxaliplatin-induced sinusoidal obstruction syndrome.

Here, we report a case of a 71-year-old man who developed non-cirrhotic portal hypertension after oxaliplatin-based adjuvant chemotherapy for rectal cancer.

Considering that portal hypertension persisted > 3 years after oxaliplatin cessation, spontaneous regression was considered unlikely.

Endoscopic injection sclerotherapy was first performed for esophageal varices, followed by n-butyl-2-cyanoacrylate injection for duodenal and gastric varices.

High-risk bleeding varices were completely eradicated without adverse events.