Successful Rapid Desensitization to Ceftazidime/Avibactam in a Patient With Cystic Fibrosis and… | ScholarDeck

Paper

Successful Rapid Desensitization to Ceftazidime/Avibactam in a Patient With Cystic Fibrosis and Multidrug-Resistant Pseudomonas aeruginosa Pneumonia: A Case Report.

New research · Internal Medicine

Clinical case reports · 4w

StudyClinical case reports· Aug 2026

Successful Rapid Desensitization to Ceftazidime/Avibactam in a Patient With Cystic Fibrosis and Multidrug-Resistant Pseudomonas aeruginosa Pneumonia: A Case Report.

Zuoren Zhou, Jinqi Zhu, Ge Wu … Yan Jiang

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Pulmonology & Critical CareStudyTreatment

13-step rapid desensitization let a patient tolerate full-dose ceftazidime/avibactam.

Successful Rapid Desensitization to Ceftazidime/Avibactam in a Patient With Cystic Fibrosis and Multidrug-Resistant Pseudomonas aeruginosa Pneumonia: A Case Report.

Zuoren Zhou … Yan Jiang

Clinical case reports · Aug 2026

Background

Ceftazidime/avibactam (CAZ-AVI) is an important therapeutic option for multidrug-resistant (multidrug-resistant) Pseudomonas aeruginosa infections; however, hypersensitivity reactions may preclude its use and create significant therapeutic challenges.

13-step

Results

13-step

protocol worked, patient tolerated full-dose treatment despite prior allergy

More results

We report a 21-year-old woman with cystic fibrosis and recurrent multidrug-resistant P. aeruginosa pneumonia who had a clinically suspected immediate hypersensitivity reaction to CAZ-AVI.

The patient subsequently tolerated full-dose CAZ-AVI therapy with marked clinical improvement.

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Conclusion

Rapid desensitization may represent an effective rescue strategy for patients with CAZ-AVI allergy when applied under strict clinical indications and multidisciplinary supervision.

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