Clinical outcomes and left ventricular recovery in patients with solid malignancies developing Takotsubo…

Cohort studyArchive of clinical cases· 2026

Clinical outcomes and left ventricular recovery in patients with solid malignancies developing Takotsubo syndrome: a retrospective cohort study.

Airton Leonardo de Oliveira Manoel, Aida Malik Al Kindy, Waleed Dawelbeit … Ahmed Mustafa Basuoni

CardiologyCohort studyPrognosis

Takotsubo syndrome in cancer patients carries high mortality, mostly from cancer, not heart failure.

Clinical outcomes and left ventricular recovery in patients with solid malignancies developing Takotsubo syndrome: a retrospective cohort study.

Airton Leonardo de Oliveira Manoel … Ahmed Mustafa Basuoni

Archive of clinical cases · 2026

Background

Takotsubo cardiomyopathy (TTS) is an acute heart failure syndrome characterized by transient left ventricle (left ventricle) systolic dysfunction, often triggered by physical or emotional stress.

Methods

We retrospectively analyzed adult patients with solid malignancies treated at a Comprehensive Cancer Center between November 2021 and December 2025 who developed Takotsubo syndrome.

n = 18 patients

Results

38.5%

Over one-third of patients died, all deaths from cancer, none from heart failure.

n = 18 patients

More results

Median age 64.5 years (IQR 52.2 - 69.5); 61.5% were female.

The median InterTAK Diagnostic Score was 75.5 (IQR 64.5-80.0); 73.1% of patients had scores ≥70.

In exploratory multivariable analysis, advanced/metastatic cancer was associated with increased odds of death (adjusted OR 11.49, p = 0.021).

More results

Follow-up echocardiography was available in 18 patients; all demonstrated normalization of left ventricular systolic function (LVEF ≥50%), with a median time to documented recovery of 10 days (IQR 6-21).

“

Conclusion · 1 of 2

Takotsubo cardiomyopathy syndrome in patients with solid malignancies was associated with high cancer-related mortality, whereas left ventricular dysfunction was largely reversible among survivors.

Conclusion · 2 of 2

Outcomes appeared to be more associated with oncologic disease burden than with cardiac dysfunction.

Clinical outcomes and left ventricular recovery in patients with solid malignancies developing Takotsubo syndrome: a retrospective cohort study.

Clinical outcomes and left ventricular recovery in patients with solid malignancies developing Takotsubo syndrome: a retrospective cohort study.

Related papers