Combined Left Ventricular and Left Atrial Strain Assessment for Long-Term Risk Stratification in Heart Failure With Reduced Ejection Fraction.

In univariable analysis, both left ventricular global longitudinal strain and LASr were associated with mortality.

ROC analysis identified optimal cutoff values of 7.3% for left ventricular global longitudinal strain and 9.0% for LASr.

Patients with concomitant marked impairment of both strain parameters exhibited the highest mortality risk, whereas those with the least impaired ventricular and atrial strain had the most favorable outcomes.

Patients with pronounced impairment of either parameter alone demonstrated intermediate survival.