Preserved retinal structure linked to much higher odds of good visual acuity recovery in uveitis.
What are the key predictors of visual function recovery in uveitis? A systematic review and meta-analysis unraveling structural, genetic, and immunological determinants.
Uveitis represents a heterogeneous inflammatory disorder of the uveal tract that remains a major cause of preventable blindness worldwide.
To identify and synthesize key predictors of visual function recovery in patients with uveitis-associated vision loss through a systematic review and meta-analysis.
Eligible randomized controlled trials and cohort studies evaluating clinical, structural, or genetic predictors of visual recovery were included.
Better retinal structural preservation was linked to over 2.5-fold higher odds of achieving 20/200 vision or better.
Fourteen studies met inclusion criteria.
Meta-analysis demonstrated a significant overall improvement in best-corrected visual acuity (BCVA; SMD = 0.303; p < 0.001).
Genetic polymorphisms in CCR2/CCR5 were associated with visual outcomes, although genetic evidence was limited and requires independent validation; preserved retinal architecture and longer treatment duration were consistently associated with better visual recovery.
Visual function recovery in uveitis depends on structural preservation, inflammation control, and genetic determinants.
Early detection and sustained treatment targeting retinal integrity are essential to prevent irreversible vision loss and enhance patient-specific prognostication.