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Paper

Trends, Burden, and Impact of Infections on Outcomes Among Patients With Alcohol-Associated Hepatitis: A Nationwide Analysis.

New research · Internal Medicine

Journal of clinical gastroenterology · 1mo

Cohort studyJournal of clinical gastroenterology· Jul 2026

Trends, Burden, and Impact of Infections on Outcomes Among Patients With Alcohol-Associated Hepatitis: A Nationwide Analysis.

Carol Singh, Abdelrahman Khater, Bipneet Singh … Marina Roytman

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Venous ThromboembolismCohort studyPrognosisQ2IF 2.5

Infections are linked to higher odds of in-hospital death in alcohol-associated hepatitis.

Trends, Burden, and Impact of Infections on Outcomes Among Patients With Alcohol-Associated Hepatitis: A Nationwide Analysis.

Carol Singh … Marina Roytman

Journal of clinical gastroenterology · Jul 2026

Background

Alcohol-associated hepatitis (AH), characterized by severe inflammation of the liver among patients with heavy alcohol use, has been associated with increased susceptibility to developing infections.

Purpose

This study evaluates the trends, burden, and impact of infections on the clinical course of AH.

Methods

Were stratified into 2 groups: those with and without infections.

n = 917,345 patients

Results

infections nearly doubled the odds of dying in hospital

AOR by subgroup · 95% CI

More results

Among the 917,345 patients with AH, 186,655 (20.3%) developed infections.

The most frequent infections observed included urinary tract infection (9%), pneumonia (6.0%), and skin/soft tissue infections (2.7%).

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Conclusion

The development of systemic infections in patients with AH leads to worse clinical outcomes. Early identification, management, and prevention are necessary to prevent adverse outcomes and improve the overall prognosis among these patients.

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