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New research · Internal Medicine
International journal of medical sciences · 3h
Cohort studyInternational journal of medical sciences · 2026

Risk of Peripheral Artery Disease and Venous Thromboembolism in Patients with Neuromyelitis Optic Spectrum Disorder: A Nationwide Population-Based Cohort Study.

Xin-An Chen, Chun-Nan Wu, Tung-Han Tsai … Chien-Ying Lee
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Internal MedicineCohort study

Neuromyelitis optica spectrum disorder is associated with markedly higher risk of venous thromboembolism

Risk of Peripheral Artery Disease and Venous Thromboembolism in Patients with Neuromyelitis Optic Spectrum Disorder: A Nationwide Population-Based Cohort Study.

Xin-An Chen … Chien-Ying Lee
International journal of medical sciences · 2026
Background

The relationship between Neuromyelitis optica spectrum disorder (neuromyelitis optica spectrum disorder) and specific cardiovascular outcomes, particularly macrovascular events such as peripheral artery disease (peripheral artery disease) and venous thromboembolism (venous thromboembolism), has not been examined in a population-based study.

Methods

With new-onset neuromyelitis optica spectrum disorder between 2003 and 2020.

n = 2,027 patients
Results

clot risk climbs sharply, more so with severe disease

AHR by subgroup · 95% CI
null = 1
VTE
4.81
PAD
2.26
VTE
11.69
More results

The risk of vascular events was strongly associated with disease severity.

More results

Severe neuromyelitis optica spectrum disorder was associated with markedly increased risks of peripheral artery disease (aHR = 2.26; 95% CI: 1.41-3.61) and venous thromboembolism (aHR = 11.69; 95% CI: 6.86-19.90), whereas mild and moderate disease did not significantly increase peripheral artery disease risk.

“
Conclusion · 1 of 2

Neuromyelitis optica spectrum disorder is a significant risk factor for peripheral artery disease and venous thromboembolism.

Conclusion · 2 of 2

These findings highlight the importance of proactive vascular risk assessment and preventive management in patients with neuromyelitis optica spectrum disorder.

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