Post

New research · Internal Medicine
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 3h
Meta-analysisClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2026

Diagnostic Validation of PERC and Resource Utilization in Suspected Acute Pulmonary Embolism: A Systematic Review and Meta-Analysis.

Xueyan Liu, Hua Fan, Yangyang Hai … Sirui Gu
Read paper
Internal MedicineMeta-analysis

PERC use is associated with less CT pulmonary angiography in low-risk emergency patients

Diagnostic Validation of PERC and Resource Utilization in Suspected Acute Pulmonary Embolism: A Systematic Review and Meta-Analysis.

Xueyan Liu … Sirui Gu
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2026
Background

And Aims Pulmonary embolism (pulmonary embolism) is a frequent and potentially fatal diagnosis in the emergency department (emergency department).

Purpose

This systematic review aimed to evaluate the diagnostic accuracy of PERC and its effect on reducing computed tomography pulmonary angiography (computed tomography pulmonary angiography) use.

Methods

Eligible studies enrolled emergency department patients with suspected pulmonary embolism who were classified as low risk according to the original study-specific approaches, including clinician gestalt, Wells score, revised Geneva score, or YEARS-based assessment.

n = 13,672 patients
Results

Imaging use was 15% lower when PERC applied, without compromising diagnostic safety

RR 0.85 (95% CI 0.80 to 0.91)
null = 10.800.91
CI excludes the null - significant
More results

The pooled pulmonary embolism prevalence was 7%.

The pooled sensitivity, specificity, and negative predictive value of PERC were 95% (95% CI: 89%-98%), 26% (95% CI: 16%-40%), and 98.2% (95% CI: 97.8%-99.0%), respectively.

“
Conclusion

ConclusionsPERC provides a highly sensitive and safe strategy for ruling out pulmonary embolism in low-risk emergency department patients and significantly reduces unnecessary use of advanced imaging without compromising diagnostic safety.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cohort Study
0.8%
an oversedation event needing naloxone reversal was rare
Randomized Trial
t = -4.35
intervention caregivers asked more questions than controls
Cohort Study
67.8%
one-year survival was far worse than the intermediate-risk group's, roughly one in three died
Review
50-100%
rheumatoid arthritis raises blood clot risk well above the general population
Cross-sectional
SIR 9.93
risk climbs sharply when relatives cluster and clotting starts young
Study
82.5%
guideline-recommended anticoagulation reached most hospitalized af patients after screening
Study
7.74
Average knowledge score rose from 5.24 to 7.74 after the education intervention
Cohort Study
34.4%
just over a third stayed safely anticoagulated, most were not