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Cohort studyClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2026

Risk Stratification and Safety Profile of Pharmacological Prophylaxis for Venous Thromboembolism in Postpartum Women Following Cesarean Section: A Comparative Evaluation.

Bui Chi Thuong, Ta Viet Hung, Pham Dinh Nguyen

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Internal MedicineCohort study

Caprini score flagged far more postpartum women for venous thromboembolism prophylaxis than 2023 guidelines.

Risk Stratification and Safety Profile of Pharmacological Prophylaxis for Venous Thromboembolism in Postpartum Women Following Cesarean Section: A Comparative Evaluation.

Bui Chi Thuong … Pham Dinh Nguyen

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2026

Background

Venous thromboembolism (venous thromboembolism) remains a leading cause of maternal morbidity and mortality worldwide.

Purpose

This study evaluated venous thromboembolism risk stratification among postpartum women following cesarean section, compared the 2023 National Guidelines (National Guidelines) with the Caprini score, and assessed pharmacological thromboprophylaxis safety.

Methods

MethodsA single-center prospective cohort study was conducted on 386 women undergoing cesarean delivery at Nhan Dan Gia Dinh Hospital between February and July 2025.

n = 386 women

56.2%

Results

56.2%

Caprini flagged 56.2% more women for prophylaxis than the guidelines did

n = 386 women

More results

According to the 2023 National Guidelines, 71.0% of patients were classified as low risk, 15.5% as intermediate risk, and 13.5% as high risk.

Major risk factors included emergency cesarean delivery (45.3%), maternal age above 35 years (23.1%), and obesity (20.5%).

More results

Among 110 women receiving thromboprophylaxis, low-molecular-weight heparin accounted for 99.1% of treatment.

No severe hemorrhagic complications or thrombocytopenia were observed.

“

Conclusion · 1 of 2

The 2023 National Guidelines generated fewer pharmacological prophylaxis indications than the Caprini score in this cohort. low-molecular-weight heparin prophylaxis showed favorable short-term inpatient safety after cesarean delivery.

Conclusion · 2 of 2

Because follow-up was limited to hospitalization and the study was not powered for rare venous thromboembolism events, these findings should be interpreted as allocation patterns and short-term safety rather than comparative effectiveness.

Risk Stratification and Safety Profile of Pharmacological Prophylaxis for Venous Thromboembolism in Postpartum Women Following Cesarean Section: A Comparative Evaluation.

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