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Cohort studyThe Journal of rheumatology · 2026

Comparative Performance of SLECRISK and PREVENT for Cardiovascular Risk Prediction in Systemic Lupus Erythematosus.

Youngmin Kim, Hongshu Guan, May Y Choi … Karen H Costenbader

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RheumatologyCohort study

SLECRISK shows higher sensitivity for predicting major adverse cardiovascular events.

Comparative Performance of SLECRISK and PREVENT for Cardiovascular Risk Prediction in Systemic Lupus Erythematosus.

Youngmin Kim … Karen H Costenbader

The Journal of rheumatology · 2026

Purpose

We compared the predictive performance of SLECRISK, an SLE-specific 10-year CVD risk model, to the new PREVENT (Predicting Risk of cardiovascular disease EVENT) model in our SLE cohort.

Methods

Adult SLE patients meeting ACR 1997 and/or EULAR criteria were included.

n = 1,243 patients

Results

SLECRISK identified more patients who developed major adverse cardiovascular events

0.74

SLECRISK sensitivity

0.29

PREVENT sensitivity

More results

581 patients (46.7%) were classified as moderate/high risk by either model: 490 by SLECRISK only and 91 by PREVENT only or by both PREVENT and SLECRISK.

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Conclusion · 1 of 3

Although overall discrimination was similar, SLECRISK demonstrated better agreement between predicted and observed cardiovascular events and higher sensitivity for identifying patients who developed MACE.

Conclusion · 2 of 3

In SLE, where younger patients may develop cardiovascular events without many traditional risk factors, failure to identify at-risk individuals may carry greater clinical consequences than overestimating risk.

Conclusion · 3 of 3

These findings suggest a role for SLECRISK as a diseasespecific tool for cardiovascular risk stratification in SLE.

Post

Comparative Performance of SLECRISK and PREVENT for Cardiovascular Risk Prediction in Systemic Lupus Erythematosus.

SLECRISK shows higher sensitivity for predicting major adverse cardiovascular events.

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