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New research · Ophthalmology
Japanese journal of ophthalmology · 2d
Cohort studyJapanese journal of ophthalmology · 2026

Descemet membrane endothelial keratoplasty versus descemet's stripping automated endothelial keratoplasty following glaucoma filtering surgery: clinical outcomes and immunologic considerations.

Hirotsugu Kasamatsu, Shizuka Koh, Yukari Yagi-Yaguchi … Takefumi Yamaguchi
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OphthalmologyCohort study

Descemet membrane endothelial keratoplasty gives sharper vision at 3 months than DSAEK after glaucoma surgery.

Descemet membrane endothelial keratoplasty versus descemet's stripping automated endothelial keratoplasty following glaucoma filtering surgery: clinical outcomes and immunologic considerations.

Hirotsugu Kasamatsu … Takefumi Yamaguchi
Japanese journal of ophthalmology · 2026
Purpose

To investigate the clinical outcomes and immunologic implications following Descemet membrane endothelial keratoplasty (descemet membrane endothelial keratoplasty) and Descemet's stripping automated endothelial keratoplasty (DSAEK) in eyes with prior glaucoma filtering surgery (glaucoma filtering surgery).

Methods

Retrospective comparative case series.

n = 29 eyes
0.4
Results
0.4
± 0.4 vs. 0.8 ± 0.4
sharper vision at 3 months with descemet membrane endothelial keratoplasty than DSAEK
n = 29 eyes
More results

Graft detachment rates were similar between the groups; rebubbling and PGF occurred only after DSAEK (14% and 9%).

“
Conclusion · 1 of 2

Descemet membrane endothelial keratoplasty appears to be a viable option after glaucoma filtering surgery, given its favorable clinical profile.

Conclusion · 2 of 2

However, the relatively high incidence of immunologic events in both groups suggests that alterations in the ocular immune environment following glaucoma filtering surgery may influence postoperative outcomes.

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