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Paper

Utility of liquid-based cytology and cell block obtained by vitrectomy under infusion to diagnose vitreoretinal lymphoma.

New research · Ophthalmology

Japanese journal of ophthalmology · 1mo

StudyJapanese journal of ophthalmology· Jun 2026

Utility of liquid-based cytology and cell block obtained by vitrectomy under infusion to diagnose vitreoretinal lymphoma.

Rintaro Ohe, Sonoka Oyanagi, Eriko Inamura … Yutaka Kaneko

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Ocular OncologyStudyDiagnosisQ1IF 2.7

Liquid-based cytology found abnormal large lymphoma cells in most vitreous samples tested.

Utility of liquid-based cytology and cell block obtained by vitrectomy under infusion to diagnose vitreoretinal lymphoma.

Rintaro Ohe … Yutaka Kaneko

Japanese journal of ophthalmology · Jun 2026 · Q1 in Ophthalmology

Purpose

To confirm the definitive diagnostic method of vitreoretinal lymphoma by vitrectomy under infusion.

Methods

Retrospective, Twenty-two patients participated in this study; 29 vitreous samples were obtained under infusion.

89.7%

Results

89.7%

atypical lymphoma cells were found in nearly all vitreous samples tested

More results

These samples contained between 30 and over 10,000 atypical large lymphoid cells.

Necrosis was observed in 76.9% in the background of liquid-based cytology samples.

In cell block samples, atypical large lymphoid cells were identified in 87.0%.

More results

Immunohistochemical staining revealed the following immunophenotypes for the lymphoid cells: CD20 (100%), CD79a (100%), CD10 (0%), BCL6 (57.1%), MUM1 (85.7%), and Ki-67 LI 66.3±12.7%.

“

Conclusion

This method ensures safety and high diagnostic accuracy, thereby contributing to the definitive diagnosis of vitreoretinal lymphoma.

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