Post

New research · Ophthalmology
Japanese journal of ophthalmology · 4d
StudyJapanese journal of ophthalmology · 2026

Utility of liquid-based cytology and cell block obtained by vitrectomy under infusion to diagnose vitreoretinal lymphoma.

Rintaro Ohe, Sonoka Oyanagi, Eriko Inamura … Yutaka Kaneko
Read paper
OphthalmologyStudy

Liquid-based cytology found abnormal large lymphoma cells in most vitreous samples tested.

Utility of liquid-based cytology and cell block obtained by vitrectomy under infusion to diagnose vitreoretinal lymphoma.

Rintaro Ohe … Yutaka Kaneko
Japanese journal of ophthalmology · 2026
Purpose

To confirm the definitive diagnostic method of vitreoretinal lymphoma by vitrectomy under infusion.

Methods

Retrospective, Twenty-two patients participated in this study; 29 vitreous samples were obtained under infusion.

89.7%
Results
89.7%
atypical lymphoma cells were found in nearly all vitreous samples tested
More results

These samples contained between 30 and over 10,000 atypical large lymphoid cells.

Necrosis was observed in 76.9% in the background of liquid-based cytology samples.

In cell block samples, atypical large lymphoid cells were identified in 87.0%.

More results

Immunohistochemical staining revealed the following immunophenotypes for the lymphoid cells: CD20 (100%), CD79a (100%), CD10 (0%), BCL6 (57.1%), MUM1 (85.7%), and Ki-67 LI 66.3±12.7%.

“
Conclusion

This method ensures safety and high diagnostic accuracy, thereby contributing to the definitive diagnosis of vitreoretinal lymphoma.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
AI / Informatics
0·962 for OCT
MerMED-FM was very accurate at diagnosing diseases using eye scans
AI / Informatics
0.98
Artificial intelligence's eyelid-height measurements matched doctors' manual measurements almost perfectly
AI / Informatics
92.1%
combining eye scans and photos correctly told benign from cancerous lesions apart nearly every time
Cohort Study
28.6%
recurred locally in more than 1 in 4 patients over years of follow-up
Cohort Study
-0.395
excision group's post-op eyelid fullness score was lower - greater improvement
Cohort Study
86.7%
of infants probed after 12 months still had unresolved tear duct blockage
Observational
16%
eyelid tissue in rosacea patients showed less of this key repair-signaling protein inside cell nuclei
Cohort Study
25%
about 1 in 4 treated cases had symptoms return after improving