The associations among iron metabolism markers, iron supplementation regimen, and sepsis-induced myocardial…

Cohort studyFrontiers in nutrition· 2026

The associations among iron metabolism markers, iron supplementation regimen, and sepsis-induced myocardial injury: a retrospective study.

Xijia Wang, Xiaoying Wang, Yanling Liu … Silong Wu

Pulmonology & Critical CareCohort studyPrognosisQ1IF 5.2

Intravenous iron supplementation was associated with a lower 30-day mortality rate in sepsis.

The associations among iron metabolism markers, iron supplementation regimen, and sepsis-induced myocardial injury: a retrospective study.

Xijia Wang … Silong Wu

Frontiers in nutrition · 2026

Background

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response, among which sepsis-induced myocardial injury (sepsis-induced myocardial injury) is a common and severe complication.

Purpose

This study aimed to investigate these associations.

Methods

Based on the MIMIC-IV database, a retrospective cohort analysis was conducted in adult patients with sepsis admitted to the intensive care unit (intensive care unit).

n = 3,360 patients

Results

intravenous iron was linked to a much lower 30-day death rate in severe infection

HR 1.56 (95% CI 1.20 to 2.04)

CI excludes the null - significant

More results

Hyperferritinemia was associated with an increased 30-day mortality (hazard ratio (HR) = 1.56, 95% confidence interval (CI): 1.195-2.038, p < 0.001).

In contrast, higher transferrin levels (HR = 0.552, p < 0.001) and higher total iron-binding capacity (total iron-binding capacity) (HR = 0.559, p < 0.001) exhibited protective effects.

More results

Serum iron levels did not correlate well with mortality.

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Conclusion · 1 of 2

Ferritin, transferrin, and total iron-binding capacity (total iron-binding capacity) are of significant value for risk stratification in sepsis.

Conclusion · 2 of 2

Intravenous iron supplementation may improve short-term prognosis without increasing the risk of subsequent sepsis-induced myocardial injury; however, this conclusion requires validation through prospective studies.

The associations among iron metabolism markers, iron supplementation regimen, and sepsis-induced myocardial injury: a retrospective study.

The associations among iron metabolism markers, iron supplementation regimen, and sepsis-induced myocardial injury: a retrospective study.

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