Impact of Helicobacter pylori Infection Status on SEPTIN9 and SDC2 Methylation Levels and Their Association…

Cohort studyThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology· Jul 2026

Impact of Helicobacter pylori Infection Status on SEPTIN9 and SDC2 Methylation Levels and Their Association with Clinical Outcomes in Elderly Patients with Gastric Mucosal Intestinal Metaplasia.

Zhuwen Yu, Haoxiang Ni, Xiaojuan Chen, Kunting Xiao

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GeriatricsCohort studyPrognosisQ3IF 1.9

Both methylation markers positive at baseline linked to higher progression risk in gastric intestinal metaplasia

Impact of Helicobacter pylori Infection Status on SEPTIN9 and SDC2 Methylation Levels and Their Association with Clinical Outcomes in Elderly Patients with Gastric Mucosal Intestinal Metaplasia.

Zhuwen Yu … Kunting Xiao

The Turkish journal of gastroenterology · Jul 2026

Background

The impact of dynamic Helicobacter pylori (Hp) infection status on DNA methylation and progression risk in elderly patients with gastric intestinal metaplasia (intestinal metaplasia) remains unclear.

Purpose

This study evaluated the associations of Hp infection status with SEPTIN9 and SDC2 methylation levels and whether baseline methylation markers were associated with subsequent clinical outcomes.

Methods

This single-center retrospective cohort study enrolled 200 older adults with intestinal metaplasia.

n = 38 patients

Results

Patients positive for both markers had about 3 times the progression rate

HR 3.12 (95% CI 1.53 to 6.38)

CI excludes the null - significant

More results

Persistent Hp infection was associated with higher SEPTIN9 and SDC2 methylation levels (P < .01).

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Conclusion · 1 of 2

Baseline SEPTIN9 and SDC2 methylation levels differed according to the Hp infection status, with the highest levels observed among patients with persistent Hp infection.

Conclusion · 2 of 2

Baseline combined methylation status was associated with an increased risk of intestinal metaplasia progression and may provide incremental value for risk stratification. These findings should be interpreted as baseline associations.

Impact of Helicobacter pylori Infection Status on SEPTIN9 and SDC2 Methylation Levels and Their Association with Clinical Outcomes in Elderly Patients with Gastric Mucosal Intestinal Metaplasia.

Impact of Helicobacter pylori Infection Status on SEPTIN9 and SDC2 Methylation Levels and Their Association with Clinical Outcomes in Elderly Patients with Gastric Mucosal Intestinal Metaplasia.

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