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New research · Nephrology
British journal of haematology · 22h
GuidelineBritish journal of haematology · 2026

Early diagnosis of AL amyloidosis in haematology, cardiology, neurology, renal and general clinics: A British Society for Haematology Guideline.

Mamta Garg, Satarupa Choudhuri, Christopher Parrish … Ashutosh Wechalekar
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NephrologyGuideline

Early diagnosis of AL amyloidosis is linked to approximately 80% 5-year survival.

Early diagnosis of AL amyloidosis in haematology, cardiology, neurology, renal and general clinics: A British Society for Haematology Guideline.

Mamta Garg et al. · British journal of haematology · 2026
Background

AL amyloidosis is caused by a plasma cell clone that produces abnormal light chains that misfold and deposit as amyloid fibrils in tissues and thus affect organ function.

Purpose

The aim of this guideline is to facilitate recognition and raise suspicion of amyloidosis.

Methods

With early-stage disease can expect approximately 80% survival at 5 years with contemporary treatment, compared to less than 30% for those with advanced disease.

Results
how many people with early AL amyloidosis are expected to live for 5 years
More results

The survival of patients with systemic amyloid light-chain (AL) amyloidosis largely depends on the extent of end-organ damage.

“
Conclusion

It is important to recognise that amyloidosis can present in any clinic, including general medicine/care of the elderly and general practice.

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