Population Toxicodynamic Modeling of the Acute Kidney Injury-to-Chronic Kidney Disease Transition Following Repeated Cisplatin Administration in Rats.

However, the quantitative dynamics underlying the AKI-to-CKD transition remain unclear.

Rats received three cycles of CDDP at 21-d intervals under different dosing regimens, but with an identical cumulative dose (9 mg/kg).

A toxicodynamic model based on Cr mass balance was developed.

Renal function progressively decreased in a dose-dependent manner across cycles.