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New research · Allergy & Immunology
Contact dermatitis · 23h
Cohort studyContact dermatitis · 2026

Sodium Metabisulphite Contact Allergy: Think Wine and Food!

Thomas R Brasher, Amanda Palmer, Rosemary L Nixon
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Allergy & ImmunologyCohort study

Alcoholic beverages, mainly wine, were the most common source of sodium metabisulphite allergy.

Sodium Metabisulphite Contact Allergy: Think Wine and Food!

Thomas R Brasher et al. · Contact dermatitis · 2026
Background

Sodium metabisulphite (SMBS) is a known contact hapten in beverages, foodstuffs, hair dyes, topical and systemic medications, and cosmetics.

Purpose

To investigate SMBS contact allergy in our tertiary referral patch testing clinics.

Methods

A retrospective audit was performed of 1367 patients patch tested to 1.0% SMBS in petrolatum between 1/1/2014 and 31/12/2023, and added to the Australian Baseline Series in 2020.

n = 1367 patients
50%
Results
half of relevant SMBS allergies were from alcoholic drinks, mostly wine
n = 1367 patients
More results

87/1367 (6.4%) patients patch tested to SMBS had a positive reaction; 24/87 (27.6%) of these reactions were relevant.

Eight (33.3%) cases presented with oral lichen planus (OLP) whilst four (16.7%) presented with allergic contact cheilitis (ACC).

Overall, 19 (79.2%) patients had facial, oral or lip-related involvement.

More results

Eight patients had more than one source of exposure.

“
Conclusion

SMBS contact allergy is not uncommon, but relevance can be difficult to ascertain. OLP, ACC, and facial rashes predominated. Wine and foodstuffs were the most important sources of exposure. SMBS should be included in baseline patch series.

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