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New research · Gastroenterology
Journal of veterinary internal medicine · 23h
Animal / preclinicalJournal of veterinary internal medicine · 2026

Successful treatment of severe iatrogenic hypercalcemia and acute kidney injury with hemodialysis in a cat.

Lauren A DelMaestro, Rebecca T Bernstein, Peter S Chapman, Nolan V Chalifoux
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GastroenterologyAnimal / preclinical

Hemodialysis normalized acute kidney injury in a cat.

Successful treatment of severe iatrogenic hypercalcemia and acute kidney injury with hemodialysis in a cat.

Lauren A DelMaestro et al. · Journal of veterinary internal medicine · 2026
Background

A 4-year-old male castrated domestic shorthair cat was diagnosed with a urethral obstruction after presenting for vomiting, inappetence, and inappropriate urination.

1.01
Results
mg/dL
Creatinine (kidney function marker) normalized to 1.01 mg/dL within 72 hours.
More results

The cat developed iatrogenic hypercalcemia (ionized calcium > 4 mmol/L, total calcium 57 mg/dL) and an acute kidney injury (creatinine 9.81 mg/dL) suspected to be a consequence of an overdose of calcium gluconate.

Approximately 12 h after admission, the cat became comatose and developed cardiovascular instability.

More results

The cat subsequently developed signs of upper respiratory and gastrointestinal disease.

Diagnostics including upper gastrointestinal endoscopy and bronchoscopy showed evidence of diffuse calcification of the trachea and gastric mucosa.

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Conclusion

This case demonstrates the successful application of hemodialysis in veterinary medicine to treat an acute kidney injury and iatrogenic hypercalcemia and provides unique documentation of its potential long-term sequelae.

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