Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial.

Here we conducted a pragmatic, cluster-randomized trial in 16 primary care facilities in Kenya.

The primary outcome was an expert-adjudicated composite of treatment failure events experienced within 14 days of enrollment.

The primary outcome did not differ significantly between groups.

In this trial, large language models assistance was safe but did not reduce treatment failure within 14 days and any benefit, if present, is probably modest.