Pharmacologic Treatments With Lifestyle Modifications in Nonpregnant Adults With Overweight or Obesity in…

ReviewAnnals of internal medicine· Jun 2026

Pharmacologic Treatments With Lifestyle Modifications in Nonpregnant Adults With Overweight or Obesity in Outpatient Settings: A Living Clinical Guideline From the American College of Physicians (April 2026).

Amir Qaseem, J Thomas Cross, Curtis S Harrod … Clinical Guidelines Committee of the American College of Physicians

Internal MedicineReviewTreatmentQ1IF 3.9

Pharmacologic treatments are suggested for adults with obesity (BMI ≥30 kg/m 2).

Pharmacologic Treatments With Lifestyle Modifications in Nonpregnant Adults With Overweight or Obesity in Outpatient Settings: A Living Clinical Guideline From the American College of Physicians (April 2026).

Amir Qaseem … Clinical Guidelines Committee of the American College of Physicians

Annals of internal medicine · Jun 2026 · Q1 in Internal Medicine

Background

DESCRIPTION: The American College of Physicians (American College of Physicians) developed this clinical guideline for internal medicine physicians and other clinicians caring in outpatient settings for adults with overweight or obesity.

Methods

This guideline is based on systematic reviews of pharmacologic treatments in adults with overweight or obesity and used the Grading of Recommendations Assessment, Development and Evaluation (Grading of Recommendations Assessment, Development and Evaluation) approach.

≥30 kg/m 2

Results

≥30 kg/m 2

a body mass index that is 30 or higher, indicating obesity

“

Conclusion

When initiating a recommended medication for weight management or switching to another recommended medication because of an inadequate response, clinicians and patients should discuss benefits, harms, costs, access and availability, clinical comorbidities, weight loss goals, life expectancy, values and preferences, and contraindications and warnings (for example, use in pregnancy).

Pharmacologic Treatments With Lifestyle Modifications in Nonpregnant Adults With Overweight or Obesity in Outpatient Settings: A Living Clinical Guideline From the American College of Physicians (April 2026).

Pharmacologic Treatments With Lifestyle Modifications in Nonpregnant Adults With Overweight or Obesity in Outpatient Settings: A Living Clinical Guideline From the American College of Physicians (April 2026).

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