Risk-based pathology reporting after endoscopic submucosal dissection for early gastrointestinal cancer: international consensus standards.
International experts developed 56 consensus recommendations for endoscopic submucosal dissection pathology reporting.
Risk-based pathology reporting after endoscopic submucosal dissection for early gastrointestinal cancer: international consensus standards.
Endoscopic submucosal dissection (endoscopic submucosal dissection) enables en bloc resection of early gastrointestinal cancers and provides specimens suitable for precise pathological risk assessment.
To develop practical international standards for pathology assessment and reporting of invasive carcinoma in endoscopic submucosal dissection specimens.
An international panel of 42 experts, including 28 gastrointestinal pathologists and 14 therapeutic endoscopists from 15 countries, participated in a modified Delphi consensus process.
The panel recommends using Sm1-Sm3 subclassification only when the muscularis propria is present; otherwise, submucosal invasion depth should be reported in micrometres, rounded to the nearest 100 µm.
Submucosal invasion breadth should be reported in millimetres as an adjunct metric for future validation.
Tumour budding should be reported according to International Tumour Budding Consensus Conference criteria, and differentiation, histological subtype, lymphovascular invasion, perineural invasion and margin status should be integrated into composite risk assessment.
These consensus standards provide immediately implementable, synoptic-ready pathology reporting criteria after endoscopic submucosal dissection.
By standardising measurement landmarks, margin terminology, ancillary stain use and reporting of adverse histological features, they aim to reduce interinstitutional variability, improve multidisciplinary decision-making and support future validation of risk models in early gastrointestinal cancer.