What should the urologist know on the management of kidney cancer in patients with Von Hippel-Lindau…

GuidelineWorld journal of urology· Jun 2026

What should the urologist know on the management of kidney cancer in patients with Von Hippel-Lindau syndrome? Recommendations of the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer Working Group.

Selcuk Erdem, Daniele Amparore, Chiara Re … EAU-YAU Renal Cancer Working Group

NephrologyGuidelineClinical practiceQ1IF 2.9

Renal cell carcinoma affects almost 30% of patients with Von Hippel-Lindau syndrome.

What should the urologist know on the management of kidney cancer in patients with Von Hippel-Lindau syndrome? Recommendations of the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer Working Group.

Selcuk Erdem … EAU-YAU Renal Cancer Working Group

World journal of urology · Jun 2026 · Q1 in Urology

Background

Renal cell carcinoma (renal cell carcinoma) is a common manifestation in Von-Hippel Lindau (Von-Hippel Lindau) syndrome, accounting for almost 30% of the patients.

Purpose

This article aims to provide evidence-based insights for diagnosis, treatment, and surveillance in Von-Hippel Lindau patients with renal cell carcinoma.

Methods

The articles indexed between 1977 and 2025 in PubMed was searched.

Results

almost 30%

people with Von-Hippel Lindau syndrome are affected by kidney cancer

More results

Renal cysts are quite common in Von-Hippel Lindau patients and these cysts predispose for renal cell carcinoma.

Von-Hippel Lindau patients are characterized with early-onset, multifocal and/or bilateral, recurrent and clear cell subtype renal cell carcinoma.

Patients should be monitored at regular intervals.

More results

Focal treatments should be considered in patients for whom surgery is not suitable.

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Conclusion · 1 of 2

In Von-Hippel Lindau patients with renal cell carcinoma, kidney function should be preserved whenever possible to ensure a long and high-quality life.

Conclusion · 2 of 2

Since these patients may develop lesions in other organs beyond kidney, surveillance with multidisciplinary approach in tertiary centers should be recommended.

What should the urologist know on the management of kidney cancer in patients with Von Hippel-Lindau syndrome? Recommendations of the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer Working Group.

What should the urologist know on the management of kidney cancer in patients with Von Hippel-Lindau syndrome? Recommendations of the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer Working Group.

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