A Predictive Scoring Model for Perioperative Psychiatric Symptom Exacerbation in Schizophrenia Spectrum…

Cohort studyJournal of the Academy of Consultation-Liaison Psychiatry· Jul 2026

A Predictive Scoring Model for Perioperative Psychiatric Symptom Exacerbation in Schizophrenia Spectrum Disorders: Development and Internal Validation.

Yoshihiro Matsumoto, Nobutaka Ayani, Masaki Fujiwara … Jin Narumoto

Psychotic DisordersCohort studyPrognosisQ2IF 1.6

New scoring model helps identify patients unlikely to have psychiatric worsening.

A Predictive Scoring Model for Perioperative Psychiatric Symptom Exacerbation in Schizophrenia Spectrum Disorders: Development and Internal Validation.

Yoshihiro Matsumoto … Jin Narumoto

Journal of the Academy of Consultation-Liaison Psychiatry · Jul 2026 · Q2 in Psychiatry

Background

With schizophrenia spectrum disorders (schizophrenia spectrum disorders) are vulnerable to clinically significant perioperative psychiatric deterioration, including delirium, which may require consultation-liaison psychiatry management and complicate medical and surgical care in general hospitals.

Methods

We conducted a retrospective multicenter registry study of patients with schizophrenia spectrum disorders admitted to non-psychiatric wards for surgical treatment at three general acute care hospitals in Japan between April 2017 and March 2022.

n = 200 patients

95.5%

Results

95.5%

patients identified as low risk by the model did not experience psychiatric worsening

n = 200 patients

More results

Among 200 patients, perioperative psychiatric symptom exacerbation occurred in 25 (12.5%).

Emergency surgery, operative time ≥180 minutes, and admission from another hospital or facility were retained in the final multivariable model.

The simplified score (0-3) showed acceptable discrimination (optimism-adjusted AUC 0.741).

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Conclusion · 1 of 2

This preliminary scoring model showed high sensitivity and negative predictive value in internal validation and may provide a framework for future validation as a perioperative triage-support tool.

Conclusion · 2 of 2

External validation is required before routine clinical implementation.

A Predictive Scoring Model for Perioperative Psychiatric Symptom Exacerbation in Schizophrenia Spectrum Disorders: Development and Internal Validation.

A Predictive Scoring Model for Perioperative Psychiatric Symptom Exacerbation in Schizophrenia Spectrum Disorders: Development and Internal Validation.

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